Targeted protein degradation is a powerful potential therapeutic approach. Here, cancer-related protein BCL6 is bound by a novel small molecule inhibitor (blue) that causes filament formation and subsequent degradation.
Molecular Interaction Guides Neurons in Developing Brain
In this journal cover design, three molecules (Teneurin-Latrophilin-FLRT, foreground) interact between radial glial cells and neurons (green and blue, background) in the developing brain to ensure the neurons migrate correctly. The bright region where the molecules interact is better understood than the darker regions.
