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The Loopy Genome
The trick to fitting 2 meters of DNA into a 0.000006 meter wide nucleus *and* keeping it organized? Loops. Lots of loops.
This 1.5 page spread for Scientific American illustrates the relationship of DNA to chromatin, the density of chromatin packing in the nucleus, and schematically show how chromatin loops are formed that both prevent entanglement and allow for gene regulation.
Created with Maxon Cinema4D, Adobe Photoshop, and Adobe Illustrator.
Illustration for Aiden EL. Untangling the Genome. Sci Am. 2019 Mar;320(3):54–5.